PRMD: an integrated database for plant RNA modifications
Xiaoqiang Lang† ,Chunyan Yu† ,Mengyuan Shen† ,Lei Gu ,Qian Qian, Degui Zhou , Jiantao Tan , Yiliang Li , Xin Peng , Shu Diao , Zhujun Deng , Zhaohui Ruan , Zhi Xu , Junlian Xing , Chen Li , Runfeng Wang, Changjun Ding* , Yi Cao* and Qi Liu*
Nucleic Acids Research
Abstract
The scope and function of RNA modifications in model plant systems have been extensively studied, resulting in the identification of an increasing number of no v el RNA modifications in recent years. R esearchers ha v e gradually re v ealed that RNA modifications, especially N 6 -methyladenosine (m 6 A), which is one of the most abundant and commonly studied RNA modifications in plants, have important roles in ph y siological and patho- logical processes. These modifications alter the str uct ure of RNA, which affects its molecular complement arit y and binding to specific proteins, thereby resulting in various of physiological effects. The increasing interest in plant RNA modifications has necessitated research into RNA modi- fications and associated datasets. However, there is a lack of a convenient and integrated database with comprehensive annotations and intuitive visualization of plant RNA modifications. Here, wedeveloped the Plant RNA Modification Database (PRMD; http:// bioinformatics.sc.cn/ PRMD and http:// rnainformatics.org.cn/ PRMD ) to facilitate RNA modification research. This dat abase cont ains information regarding 20 plant species and provides an intuitiv e interf ace f or displa ying inf ormation. Moreo v er, PRMD offers multiple tools, including RMle v elDiff , RMplantVar, RNAmodNet and Blast (for functional analyses), and mRNAbrowse, RNAlollipop, JBrowse and Integrative Genomics Viewer (for displaying data). Furthermore, PRMD is freely a v ailable, making it useful for the rapid development and promotion of research on plant RNA modifications.
附件：PRMD.pdf
